Science
AeroLEF® has been specifically designed to fulfill unmet needs by providing rapid and extended analgesia, tailored for each episode of moderate to severe acute pain. A patient continues to inhale until the dose provides appropriate pain relief. This self-titration ensures a tailored dose unique to each individual pain episode.
AeroLEF Phase I pharmacokinetic and pharmacodynamic studies confirmed that appropriate therapeutic plasma concentrations (0.5 to 2 ng/mL) are achieved during inhalation dosing. In addition, the maximum plasma concentration is realized at the end of dosing, an outcome that offers the potential for patients to safely self-titrate their AeroLEF to meaningful analgesia and avoid the delayed, and significant overshoot and dose stacking issues associated with current fixed dose delivery methods.
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Manuscripts
Posters and Abstracts
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Clark AJ, et al. Aerosolized Free and Liposome-Encapsulated Fentanyl (AeroLEF) via pulmonary administration allows patients with moderate to severe post-surgical acute pain to self-titrate to effective analgesia. American Pain Society (APS) Annual Meeting, 2008 (abstr 264) |
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Brull R, et al. A randomized controlled trial demonstrates the efficacy, safety and tolerability of Aerosolized Free and Liposome-Encapsulated Fentanyl (AeroLEF) via pulmonary administration. American Pain Society (APS) Annual Meeting, 2008 (abstr 265) |
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Hung OR, Pliura DH. Comparative Phase I PK study of Aerosolized Free and Liposome-Encapsulated Fentanyl (AeroLEF) demonstrates rapid and extended plasma fentanyl concentrations following inhalation. American Pain Society (APS) Annual Meeting, 2008 (abstr 243) |
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Brull R, et al. A Randomized Double-Blind Placebo-Controlled Trial of AeroLEF (Aerosolized Free and Liposome-Encapsulated Fentanyl) for Post‑Operative Pain following Orthopedic Surgery. American Society of Regional Anesthesia and Pain Medicine (ASRA) Annual Meeting, 2007 (abstr A-16) |
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Chisholm KC, et al. Inhaled Liposome-Encapsulated Fentanyl (AeroLEF) for Post-Operative Pain after Orthopedic Surgery. American Society of Anesthesiologists (ASA) Annual Meeting, 2006 (abstr A-1191)
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